Anavar Review. Action of the drug. Dosage, Side Effects, Cycles, How to take

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Anavar (oxandrolone)[edit]

Anavar Effects

Oxandrolone (also known as Oxandrolin, Anavar, Oksandrin, Vasorome, Anatrofill, etc.) is an anabolic steroid, created by Searle Laboratories. and released under the trade mark Anavar in 1964.

Oxandrolone is a synthetic steroid, its ring A is a heterocycle, wherein the second carbon atom is substituted with an oxygen atom. Oxandrolone is widely known because of its extremely low level of Androgenic activity and high Anabolic index.

It has the highest immunostimulatory effect among steroids, and it significantly increases the sensitivity of tissues to Insulin. Initially, oxandrolone has been developed for the treatment of debilitated HIV-infected patients with osteoporosis, osteochondrosis, Turner syndrome, anemia, also to speed up recovery after burns, prolonged bed rest, in type II diabetes associated with obesity. Soon it stated to be actively used in bodybuilding, then Anavar was listed as a controlled substance.

Steroid profile[edit]

  • Anabolic Activity - 400% of Testosterone
  • Androgenic Activity - 25% of testosterone
  • Aromatization (conversion to estrogen) - No
  • Hepatotoxicity - moderate / weak
  • Method of use - oral (tablets)
  • The half-life - 8-12 hours
  • Detection time - up to 60 days


  • Increased hardness of lean muscles - the main effect of oxandrolone
  • Fat burning
  • Increased level of the HGH
  • Increased strength

Anavar is ineffective for muscle mass gain. Anavar cycle is recommended for people who have sufficiently moderate muscle mass and moderate fat in the body.

Oxandrolone for fat loss[edit]

Scientists from the University of Southern California made an experiment, which showed that the lost adipose tissue doesn’t returned immediately after the cancellation of the steroid.

The study was sponsored by the US government and by manufacturer of oxandrolone - Savient. Men that weren’t lifting weights and were older than 60, took part in the experiment, which lasted 12 weeks.

The study showed that men did not only get rid of fat, but they also gained some muscle mass in 12 weeks, even without strength trainings. The daily dosage of the steroid was 20 mg; adipose tissue loss was 1.8 kg. However, during the next 12 weeks gained muscle mass was gone but the effect of fat loss remained. Only 17% of adipose tissue returned. Furthermore, it was found that major changes in body composition occurred during the first 6 weeks. That’s why they refer to short cycles of oxandrolone as the most effective.

Loss of adipose tissue (cm2)

Belly fat 25
Subcutaneous Fat 10
Hip Fat 8
Knee Fat 3
Intramuscular adipose tissue of the body 8
Intramuscular adipose tissue of limbs 2

Scientists concluded that oxandrolone is more effective drug for fat loss than for muscle mass gain. But do not forget that the loss of 2 kg of fat tissue in 12 weeks is easily achievable without taking AAS.

The study also found that while burning fat, sensitivity to Insulin was increasing. The body was able to do less of this hormone in response to the receipt of food substrates into the blood, and the risk of conversion of glucose into fat decreased.

Side effects[edit]

Despite the fact that oxandrolone is a 17-alpha alkylated steroid, its toxic effect on the liver is weak. Studies show that taking 20 mg of Anavar 20 per day during 12 weeks doesn’t affect the level of liver enzymes. The first signs of liver damage are a pain in the right upper quadrant, light stools and dark urine. Since Anavar is a derivative of Dihydrotestosterone, it does not aromatize (doesn’t converted into estrogen, which cause side effects such as gynecomastia and water retention in the body).

Oxandrolone in moderate doses has no significant effect on the level of natural Testosterone production. When the dosage of Anavar is high, the body decreases gonadotropin production, thinking that endogenous testosterone level is too high. Lack of stimulation of Leydig cells leads to testicular atrophy. Oxandrolone, used in a dose of 80 mg per day suppresses testosterone levels by 67% after 12 weeks.

Suppression of testosterone production is manifested by decreased libido and erectile dysfunction. Fixing the side-effect of oxandrolone s possible by adding gonadotropin in the cycle or making combined cycles with androgen drugs.

Also, there are sometimes side effects like loss of appetite, abdominal pain, nausea, headaches, rise in blood pressure and others. In general, side effects of oxandrolone are rare. Anavar is one of the safest steroids.

Oxandrolone cycle[edit]

In order to prevent some of the side effects of oxandrolone (decreased libido, erectile dysfunction, hepatotoxicity) and to get great results, it is recommended to include high-androgenic drugs in the Anavar cycle:

Also don’t forget:

  • When combined with other drugs, dosage of oxandrolone is usually about 40 mg per day.
  • Combined cycles will not only lean your muscles but will also increase muscle mass.

To maximize the effectiveness, take the complex of Sports nutrition for muscle mass gain and follow a diet for muscle mass gain.